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The authors have investigated three treatments to correct metabolic abnormalities which have demonstrated improvement in behavior and/or metabolism, namely the combination of methylcobalamin (mB12) with low-dose folinic acid (LDFA) to treat oxidative stress in an open-label study (James et al., 1A demonstrates where these agents are believed to act within four major interconnected metabolic pathways that are known to be disrupted in ASD

Novel Agents Published in Endocrinology in August, Novel Dual and Triple Agonists Targeting GLP-1, GIP, Glucagon, and GDF15 for Type 2 Diabetes and Obesity Management sets the stage for how remarkably these agents have transformed the treatment landscape and what additional benefits may lie on the horizon

When compared with injectable GLP-1 agonists, orforglipron's discontinuation rates are broadly similar

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